News Brief
On August 11, 2025, the Official Journal of the European Union published Regulation (EU) 2025/1731, which formally amended Articles 28, 29, and 30 of Annex XVII of the REACH Regulation (EC) No 1907/2006, in order to adapt to the latest changes in the EU's CLP Regulation.
This time, a total of 16 new CMR substances were added to the Annex XVII restriction list, and an exemption clause for specific uses was added for a previous CMR substance. Since the classification of substances in the latest revised EU CLP Regulation will apply from September 1, 2025, the restrictions introduced by this revision for substances newly classified as CMR 1B will also apply from the same date; the remaining provisions will come into effect on the 20th day following the publication of the regulation in the Official Journal of the European Union.
Main Amendments: Addition of 16 new CMR substances to Appendices 2, 4, and 6 of Annex XVII
Addition of 16 new CMR substances to Appendices 2, 4, and 6 of Annex XVII. Among the substances, 4-methylimidazole is both a Carcinogen and a Reproductive toxicant, and dimethyl propylphosphonate is both a Germ cell mutagen and a Reproductive toxicant.
Appendix 2: Adds 5 new Carcinogens: Category 1B substances
Substances | Index No | EC No | CAS No |
diuron (ISO); 3-(3,4-dichlorophenyl)-1,1-dimethylurea | 006-015-00-9 | 206-354-4 | 330-54-1 |
2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol; tetrabromobisphenol-A | 604-074-00-0 | 201-236-9 | 79-94-7 |
N, N-dimethyl-p-toluidine | 612-296-00-4 | 202-805-4 | 99-97-8 |
4-nitrosomorpholine | 613-346-00-8 | - | 59-89-2 |
4-methylimidazole | 613-349-00-4 | 212-497-3 | 822-36-6 |
Appendix 4: Adds 1 new Germ cell mutagen: Category 1B substance
Substances | Index No | EC No | CAS No |
dimethyl propylphosphonate | 015-208-00-7 | 242-555-3 | 18755-43-6 |
Appendix 6: Adds 12 new Reproductive toxicants: Category 1B substances
Substances | Index No | EC No | CAS No |
diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide | 015-203-00-X | 278-355-8 | 75980-60-8 |
benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate | 015-204-00-5 | 479-100-5 | 577705-90-9 |
benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[phenol] (1:1) | 015-205-00-0 | 278-305-5 | 75768-65-9 |
reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate (1:1) | 015-206-00-6 | - | - |
reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol (1:1) | 015-207-00-1 | - | - |
dimethyl propylphosphonate | 015-208-00-7 | 242-555-3 | 18755-43-6 |
dibutyltin maleate | 050-034-00-5 | 201-077-5 | 78-04-6 |
dibutyltin oxide | 050-035-00-0 | 212-449-1 | 818-08-6 |
reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane | 603-244-00-1 | - | - |
4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF | 604-099-00-7 | 216-036-7 | 1478-61-1 |
1,4-Benzenediamine, N,N’-mixed Ph and tolyl derivs.; | 612-298-00-5 | 273-227-8 | 68953-84-4 |
4-methylimidazole | 613-349-00-4 | 212-497-3 | 822-36-6 |
Exemption for Specific Uses of Cumene
Appendix 11: Adds the following provisions
Substances | Derogations |
Cumene CAS No 98-82-8 EC No 202-704-5 | As a substance on its own or as a constituent of other substances in either of the following: (a) Kerosene used as aviation fuel conforming to DEF STAN 91-091, ASTM specification D1655 or equivalent recognised standards and marketed under descriptions such as Jet-A, Jet-A1 or JP-(x); (b) Gasoline used as aviation fuel conforming to DEF STAN 91-090, ASTM D910, ASTM D7547 or equivalent recognised standards. |
Corporate Response Measures and Preparations
For substances included in Annex XVII of the EU REACH Regulation (EC) No 1907/2006, the EU restricts the circulation and use of the substances themselves and their mixtures:
The concentration of the relevant substance or its mixture must comply with the specific limits in the EU CLP Regulation (EC) No 1272/2008. When a specific concentration limit is exceeded, it is prohibited from being placed on the market or used by the general public.
For relevant substances intended for professional use, the packaging must be marked with "For professional use only" before the substance is placed on the market.
The series of restricted substances newly added to the REACH regulation are widely used in multiple fields, including the pesticide industry, coatings industry, automotive manufacturing, and electronics and electrical industry, among others. The restrictions on these substances will have a profound impact on these industries. In response, REACH24H recommends that companies continuously monitor European chemical regulatory developments and promptly check their products exported to the EU against the latest REACH restriction list. If needed, you can log in to ChemCheck24H to quickly check whether your products contain restricted substances. If a product contains the above-mentioned restricted substances, companies should promptly prepare for substance replacement and adjust sales strategies to ensure their products comply with regulatory requirements.
If you have any questions in this regard, please feel free to contact us at customer@reach24h.com.
