CHINA NEW COSMETIC INGREDIENT SUCCESS
On September 24, 2026, Hangzhou Grand Biologic Pharmaceutical Inc. (Hangzhou Grand) successfully completed the notification of Lactococcus lactis powder (乳酸乳球菌粉) as a new cosmetic ingredient (NCI) in China, with regulatory and technical support from REACH24H. The ingredient received notification number 国妆原备字20260148.
The achievement marks a milestone for probiotic-derived cosmetic ingredient innovation. According to the September 2026 project announcement, it was the first probiotic powder cosmetic ingredient to complete notification and public disclosure in China, opening a new direction for the company's proprietary microbial research.
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From Proprietary Strain Research to Cosmetic Ingredient Development
The ingredient is developed from a proprietary Lactococcus lactis strain selected from Hangzhou Grand's independently established microbial resource library. A rigorous natural screening process provides the strain with clear source traceability and a well-defined genetic background. Hangzhou Grand has further developed it into a high-purity, freeze-dried, inactivated bacterial powder for cosmetic applications.
The development draws on two complementary strengths: the strain's potential cosmetic applications and skin compatibility, and Hangzhou Grand's established capabilities in large-scale microbial cultivation and formulation processes. Together, these capabilities support the transition from laboratory research to industrial production.
REACH24H's Support: A Tailored Strategy and a Six-Month Project
For this project, REACH24H's cosmetic ingredient technical team developed a customized notification strategy tailored to the characteristics of the bacterial powder. The team worked closely with Hangzhou Grand's research and development and quality teams, combining detailed early-stage planning with thorough technical communication to coordinate the notification work.
This collaboration enabled Hangzhou Grand to obtain the NCI notification number within a six-month project period. The case illustrates how an ingredient-specific regulatory strategy and close cooperation between regulatory, research and quality specialists can support the progression of an innovative ingredient toward notification.
About Hangzhou Grand Biologic Pharmaceutical Inc.
Founded in 2004, Hangzhou Grand joined China Grand Enterprises in 2013 and is a wholly owned subsidiary of Grand Life Sciences Group. Its pharmaceutical business focuses on gastrointestinal and metabolic health.
In the probiotics field, the company has established a proprietary library of 10,000 functional microbial strains and an integrated research and development system covering strain screening, fermentation processes and quality control. The notification of Lactococcus lactis powder represents an extension of these capabilities into cosmetic ingredients, supporting the company's development of new applications for its microbial resources.
How REACH24H Supports Cosmetic Ingredient Innovation
REACH24H's cosmetic compliance team brings together more than 40 industry specialists, with expertise spanning toxicology, cosmetic safety assessment, risk assessment, formulation development and regulatory analysis, supported by multilingual service capabilities.
For companies developing biotechnology-derived and other innovative cosmetic ingredients, REACH24H provides services including:
China new cosmetic ingredient registration and notification;
Safety assessment for cosmetic ingredients and finished products;
Ingredient stability testing and coordination of toxicology and efficacy studies;
INCI name applications and customized regulatory training.
Beyond cosmetics, REACH24H also provides compliance support across pharmaceuticals, new food ingredients and chemicals, helping companies address regulatory needs across multiple product categories.
Developing an innovative ingredient for the Chinese cosmetics market?
Contact REACH24H's cosmetic regulatory experts to discuss a tailored registration or notification strategy.
Email: customer@reach24h.com
