Following the monitoring period and regulatory assessment, the ingredient was incorporated into IECIC List II together with three other ingredients. For international ingredient suppliers and cosmetic companies, these ingredients are now managed as existing cosmetic ingredients in China rather than as new cosmetic ingredients, although companies should still verify the relevant IECIC entry and applicable conditions before use.
Four Ingredients Added to IECIC List II
Under the NMPA’s current IECIC management mechanism, the Inventory is dynamically managed through List I and List II. List II includes eligible new cosmetic ingredients that have completed the required safety monitoring period and regulatory assessment. See the NMPA Announcement on the Administration of the IECIC.
The latest adjustment covers:
Ingredient | Filing No. | Filing Person |
|---|---|---|
AZELAMIDOPROPYL DIMETHYL AMINE | 国妆原备字20230002 | Corum Inc. |
CETYL DIGLYCERYL TRIS(TRIMETHYLSILOXY)SILYLETHYL DIMETHICONE | 国妆原备字20220001 | Dow (Zhangjiagang) Investment Co., Ltd. |
NICOTINAMIDE MONONUCLEOTIDE (NMN) | 国妆原备字20220013 | Yuyao Lifespan Health Technology Co., Ltd. |
BAKUCHIOL | 国妆原备字20220027 | Sytheon Corporation |
Under China’s cosmetic regulatory framework, a registered or filed new cosmetic ingredient remains subject to new ingredient management during its three-year safety monitoring period. After the monitoring period and regulatory assessment, eligible ingredients may be incorporated into the IECIC.
Importantly, the original filing date is not necessarily the start of the monitoring period. Under the Provisions for Registration and Filing of Cosmetics, the monitoring period begins when the first cosmetic product containing the ingredient completes product registration or filing.
What IECIC II Inclusion Means for Global Companies
The inclusion of these four ingredients changes their regulatory status in China and may simplify future formulation planning.
However, IECIC inclusion does not mean that an ingredient can be used without further assessment. Companies should still review:
the exact IECIC entry and ingredient identity;
the intended purpose and applicable conditions of use;
the proposed concentration and product category; and
finished-product safety assessment and other compliance requirements.
This is particularly important when global formulations are adapted for China. An ingredient widely used in the EU, United States or other markets should not automatically be assumed to meet China’s regulatory requirements.
Companies should also note that if the proposed purpose of use, safe use amount or other conditions differ from the ingredient’s existing regulatory status, an assessment under the China new cosmetic ingredient framework may still be required.
For further background, companies can review REACH24H’s guidance on how new cosmetic ingredients are defined in China.
Finished cosmetics containing these ingredients remain subject to applicable product-level requirements. Overseas brands can also refer to REACH24H’s China Cosmetic Registration & Filing/Notification Guide when assessing the finished-product market access pathway.
REACH24H-Assisted Ingredient Added to IECIC II
Among the four ingredients is AZELAMIDOPROPYL DIMETHYL AMINE, a patented cosmetic active developed by Corum Inc. under the trade name Epi-On®.
In January 2023, REACH24H assisted Corum in completing the China new cosmetic ingredient filing for the ingredient under filing number 国妆原备字20230002. After completing the required safety monitoring period and regulatory assessment, it was incorporated into IECIC List II in August 2026.
Its current List II information can be checked through the official cosmetic ingredient database of the National Institutes for Food and Drug Control (NIFDC).
The project illustrates the full regulatory pathway that may apply to an innovative ingredient entering China:
New cosmetic ingredient filing → safety monitoring → regulatory assessment → IECIC inclusion
For international ingredient developers, this highlights that regulatory planning should extend beyond the initial filing. Companies planning to introduce innovative ingredients into China can learn more about REACH24H’s China New Cosmetic Ingredient Registration & Filing Services.
Impact & Actionable Advice
International cosmetic ingredient suppliers, manufacturers and brands should consider the following actions:
Check the latest IECIC status before determining whether an ingredient requires new cosmetic ingredient registration or filing.
Review the full IECIC entry, rather than treating inclusion as unrestricted authorization.
Assess the intended function and use conditions when adapting global formulations for China.
For ingredients not covered by IECIC, determine early whether new cosmetic ingredient registration or filingis required.
Include the three-year safety monitoring period and subsequent regulatory follow-up in long-term China market-access planning.
How REACH24H Can Help
REACH24H supports international companies throughout the China new cosmetic ingredient registration and filingprocess, including:
ingredient status and regulatory pathway assessment;
registration or filing strategy;
technical dossier preparation and gap analysis;
safety assessment and testing strategy;
submission and technical review support; and
post-filing regulatory and technical support.
As of August 2026, REACH24H has supported companies in completing more than 60 cosmetic new ingredient registration and filing projects in China, covering plant-derived, biotechnology-derived, synthetic, peptide, polymer and other ingredient types.
If you are assessing whether an ingredient is covered by the latest IECIC or requires new cosmetic ingredient registration or filing in China, contact REACH24H for a project-specific regulatory assessment and market-access strategy.
